Protease Inhibitors Formed In Situ from Copper and Tridentate Chelates: A Generalized Approach towards Metal-Based Pharmaceuticals

ChemBioChem ◽  
2002 ◽  
Vol 3 (11) ◽  
pp. 1141-1143 ◽  
Author(s):  
Christopher J. Brinkerhoff ◽  
Paul Podsiadlo ◽  
Tomoko Komiyama ◽  
Robert S. Fuller ◽  
Ofer Blum
Keyword(s):  
Protease Inhibitors

SEM of non-coated hepatocellular cytoskeleton of perfused livers

1984 ◽  
Vol 42 ◽  
pp. 306-307
Author(s):  
S.W. French ◽  
N.C. Benson ◽  
C. Davis-Scibienski
Keyword(s):  
Ambient Temperature ◽  
Critical Point ◽  
Protease Inhibitors ◽  
Metal Deposition ◽  
Heat Damage ◽  
Detergent Extraction ◽  
Cytoskeletal Elements ◽  
Triton X ◽  
Excised Tissue

Previous SEM studies of liver cytoskeletal elements have encountered technical difficulties such as variable metal coating and heat damage which occurs during metal deposition. The majority of studies involving evaluation of the cell cytoskeleton have been limited to cells which could be isolated, maintained in culture as a monolayer and thus easily extracted. Detergent extraction of excised tissue by immersion has often been unsatisfactory beyond the depth of several cells. These disadvantages have been avoided in the present study. Whole C3H mouse livers were perfused in situ with 0.5% Triton X-100 in a modified Jahn's buffer including protease inhibitors. Perfusion was continued for 1 to 2 hours at ambient temperature. The liver was then perfused with a 2% buffered gluteraldehyde solution. Liver samples including spontaneous tumors were then maintained in buffered gluteraldehyde for 2 hours. Samples were processed for SEM and TEM using the modified thicarbohydrazide procedure of Malich and Wilson, cryofractured, and critical point dried (CPD). Some samples were mechanically fractured after CPD.

Inhibition of post-mortem muscle softening following in situ perfusion of protease inhibitors in tilapia

2003 ◽  
Vol 69 (3) ◽  
pp. 632-638 ◽  
Author(s):  
Noriko ISHIDA ◽  
Michiaki YAMASHITA ◽  
Naoko KOIZUMI ◽  
Makoto TERAYAMA ◽  
Toshinao INENO ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Post Mortem ◽  
In Situ Perfusion

Comparative Effects on Intestinal Absorption in Situ by P-glycoprotein-Modifying HIV Protease Inhibitors

2004 ◽  
Vol 21 (10) ◽  
pp. 1862-1866 ◽  
Author(s):  
Martin Richter ◽  
Nóra Gyémánt ◽  
Joséf Molnár ◽  
Andreas Hilgeroth
Keyword(s):  
Intestinal Absorption ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
P Glycoprotein

Rapid Diversity-Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors

ChemBioChem ◽  
2003 ◽  
Vol 4 (11) ◽  
pp. 1246-1248 ◽  
Author(s):  
Ashraf Brik ◽  
John Muldoon ◽  
Ying-Chuan Lin ◽  
John H. Elder ◽  
David S. Goodsell ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Diversity Oriented Synthesis ◽  
Microtiter Plates

Companion Protease Inhibitors for the In Situ Protection of Recombinant Proteins in Plants

2016 ◽  
pp. 115-126 ◽  
Author(s):  
Stéphanie Robert ◽  
Philippe V. Jutras ◽  
Moustafa Khalf ◽  
Marc-André D’Aoust ◽  
Marie-Claire Goulet ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Recombinant Proteins

High-Speed Synthesis of Potent C2-Symmetric HIV-1 Protease Inhibitors by In-Situ Aminocarbonylations

2005 ◽  
Vol 7 (4) ◽  
pp. 611-617 ◽  
Author(s):  
Johan Wannberg ◽  
Nils-Fredrik K. Kaiser ◽  
Lotta Vrang ◽  
Bertil Samuelsson ◽  
Mats Larhed ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
High Speed ◽  
Hiv 1

The influence of fillers and protease inhibitors in experimental resins in the protein profile of the acquired pellicle formed in situ on enamel-resin specimens

2019 ◽  
Vol 108 ◽  
pp. 104527 ◽  
Author(s):  
Vinícius Taioqui Pelá ◽  
Anuradha Prakki ◽  
Linda Wang ◽  
Talita Mendes Silva Ventura ◽  
Cíntia Maria de Souza e Silva ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Protein Profile

Rendez vous with Saturn's rings

1984 ◽  
Vol 75 ◽  
pp. 743-759 ◽  
Author(s):  
Kerry T. Nock
Keyword(s):  
Solar Energy ◽  
Electric Propulsion ◽  
Power Source ◽  
Propulsion System ◽  
Low Thrust ◽  
Ring Plane ◽  
The Earth ◽  
Total Impulse ◽  
Saturn's Rings

ABSTRACTA mission to rendezvous with the rings of Saturn is studied with regard to science rationale and instrumentation and engineering feasibility and design. Future detailedin situexploration of the rings of Saturn will require spacecraft systems with enormous propulsive capability. NASA is currently studying the critical technologies for just such a system, called Nuclear Electric Propulsion (NEP). Electric propulsion is the only technology which can effectively provide the required total impulse for this demanding mission. Furthermore, the power source must be nuclear because the solar energy reaching Saturn is only 1% of that at the Earth. An important aspect of this mission is the ability of the low thrust propulsion system to continuously boost the spacecraft above the ring plane as it spirals in toward Saturn, thus enabling scientific measurements of ring particles from only a few kilometers.

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